Severe eosinophilia and risk of major disease and mortality: A nationwide cohort study of children and adults

Journal of Allergy and Clinical Immunology Global 2026 Open access

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Authors: Shay Nemet, Daniel Elbirt, Ramon Cohen, Keren Mahlab‐Guri, Vered Shkalim Zemer, Ilan Asher, Aviv Talmon, Limor Rubin, Yaarit Ribak, Eyal Ben Dori, Inon Sarig, Nur Sagi
+3 more Ruslan Sergienko, Yuval Tal, Oded Shamriz
DOI: 10.1016/j.jacig.2026.100654
Cited by: 0
References: 33

Abstract

Background: Severe eosinophilia (SE), defined as greater than 5000 cells/μL, is uncommon but may indicate serious underlying disease. Its long-term prognostic implications across age groups remain unclear. Objectives: We sought to investigate the long-term risk of morbidity and all-cause mortality in children and adults with SE. Methods: We conducted a nationwide, population-based, matched cohort study using data from Clalit Health Services, Israel (2000-2023). Individuals with SE (n = 3822) were matched 1:10 to subjects without SE with normal eosinophil counts (

Fields of Study & Subjects

Eosinophilic Disorders and Syndromes Asthma and respiratory diseases Immunodeficiency and Autoimmune Disorders

Publication details

Journal / source
Journal of Allergy and Clinical Immunology Global
Volume
5
Issue
3
Pages
100654–100654
Publication date
4 February 2026
Language
EN