ApoA-1 versus HDL-C as markers of cardiovascular risk
Abstract
BACKGROUND: Conflicting results have been reported as to the relative importance of apolipoprotein A-1 (apoA-1) vs high-density lipoprotein cholesterol (HDL-C) as markers of atherosclerotic cardiovascular disease (ASCVD) risk. OBJECTIVE: To compare the apoA-1 and HDL-C as predictors of cardiovascular risk. METHODS: Residual discordance analysis with Cox proportional hazard models comparing apoA-1 and HDL-C as markers of ASCVD risk was applied to a sample of 291,995 UK Biobank participants, followed for a median of 11 years. Interaction tests for the 2 markers and estimation of the effects of partitioning HDL-C into apoA-1, log-triglyceride, and the remaining residual were also performed. RESULTS: ApoA-1 and HDL-C had similar associations with ASCVD risk (hazard ratios [HRs] of 0.85, P value
Fields of Study & Subjects
Adipokines
Inflammation
and Metabolic Diseases
Cardiovascular Function and Risk Factors
Diabetes
Cardiovascular Risks
and Lipoproteins
Publication details
- Journal / source
- Journal of clinical lipidology
- Publisher
- Elsevier BV
- Volume
- 20
- Issue
- 5
- Pages
- 1040–1047
- Publication date
- 26 February 2026
- Language
- EN