A real-world study on the risk of acute pancreatitis and cardiovascular events among adults with severe or extreme hypertriglyceridemia

Journal of clinical lipidology 2026 Open access

Read full text
Authors: Asia Sikora Kessler, Kirti Batra, Qiana Amos, Seth J. Baum, Daniel E. Soffer, Montserrat Vera Llonch
DOI: 10.1016/j.jacl.2026.04.002
Cited by: 1
References: 35

Abstract

BACKGROUND: Severe hypertriglyceridemia (sHTG) has a causal role in acute pancreatitis (AP), whereas the relationship between triglyceride (TG) levels and risk of cardiovascular (CV) events is less well-known. OBJECTIVE: To assess the incidence, risk, and odds of AP and CV events among US adults with sHTG and hypertriglyceridemia (HTG) compared to those with normal TG levels. METHODS: The Optum Research Database identified 4 cohorts of adults with a TG test between January 1, 2017, and March 31, 2021. sHTG (500 ≤ TG

Fields of Study & Subjects

Lipid metabolism and disorders Pancreatitis Pathology and Treatment Diabetes Cardiovascular Risks and Lipoproteins

Publication details

Journal / source
Journal of clinical lipidology
Publisher
Elsevier BV
Volume
20
Issue
6
Pages
1097–1108
Publication date
11 April 2026
Language
EN