Associations of depressive symptoms and antidepressant medication use with physical function among middle-aged adults: Results from the CARDIA Function study

Journal of Affective Disorders 2026 Open access

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Authors: Brett T Burrows, Richard Sloane, Marissa C. Ashner, Carl F. Pieper, Cora E. Lewis, Kelley Pettee Gabriel, Pamela J. Schreiner, Bjoern Hornikel, Kai Zhang, Nathaniel D.M. Jenkins, Angela Sullivan, C. Barrett Bowling
DOI: 10.1016/j.jad.2026.121324
Cited by: 1
References: 35

Abstract

Depressive symptoms (DS) are associated with lower physical function among older adults, and similar associations have been shown in middle-aged adults. However, studies have overlooked the role of antidepressant medications. We conducted a cross-sectional analysis of the Coronary Artery Risk Development in Young Adults (CARDIA) Function study. Analysis included measured physical performance and self-reported function. Elevated DS were defined by the Center of Epidemiological Studies Depression (CESD) as ≥16. Participants were grouped by level of DS (DS-:

Fields of Study & Subjects

Cardiac Health and Mental Health Treatment of Major Depression Physical Activity and Health

Publication details

Journal / source
Journal of Affective Disorders
Publisher
Elsevier BV
Volume
401
Pages
121324–121324
Publication date
2 February 2026
Language
EN