Global research hotspots and trends in polysaccharide anti-tumor therapy: A systematic bibliometric analysis and review

Polysaccharides, as natural bioactive macromolecules with anti-tumor potential, have become a research hotspot in the context of limited traditional cancer treatment methods. However, there is a lack of systematic reviews and clear delineation of future trends in this field regarding polysaccharide-based anti-tumor therapy. To fill this gap, this study aims to analyze the research hotspots and trends using bibliometric methods, providing support for promoting clinical translation. Relevant literature was retrieved from the Web of Science database, and key indicators such as annual publication volume, national/institutional collaboration models, and research hotspots were visually analyzed. The global publications on polysaccharide-based anti-tumor therapy have been on the rise. China, the United States, and India are the top three countries in terms of output. The research hotspots can be clustered into three major directions: "Polysaccharide-based nanocarriers and tumor-targeted delivery", "Polysaccharide-mediated drug delivery systems and efficacy enhancement", and "Polysaccharide anti-tumor mechanisms and tumor treatment effects". Current research focuses on nanocarrier construction, targeted delivery mechanisms, and exploration of the anti-tumor activity of natural polysaccharides. Research on polysaccharide-based anti-tumor therapy is steadily developing and has a cross-disciplinary characteristic. Based on the analysis of the research dynamics in this field, this study not only further validates and highlights the anti-tumor potential of polysaccharides, but also clearly indicates that future research will focus on precision medicine, combined treatment, and green synthesis technologies, providing key references for promoting clinical innovation and transformation in tumor treatment. • Global research on polysaccharides for anti-tumor purposes involves 4,489 publications, with China, the United States, and India being the major contributors. • China leads in the number of publications (2,090), and the United States and China form the core collaborative network. • The keyword clustering includes targeted delivery via nanocarriers, enhancing drug delivery systems, anti-cancer mechanisms and efficacy. • Polysaccharide’s exhibit multifunctionality in inducing apoptosis and regulating the immune microenvironment.