Combining Thyroid Imaging Report and Data System (TIRADS) and Afirma Genomic Sequencing Classifier (GSC) for potential improvement of malignant risk stratification of Bethesda III thyroid nodules
Abstract
This study retrospectively assessed the ultrasound parameters in Bethesda category III thyroid nodules accompanied by a diagnostic Afirma Genomic Sequencing Classifier (GSC) testing result and surgical/clinical follow-up, and investigated whether combining ultrasound and GSC classifications could improve risk stratification of AUS nodules. Data including radiologic TIRADS score, concurrent GSC test results, and surgical/clinical follow-up were collected from patients with thyroid nodules meeting the study criteria. The distribution of TIRADS scores was compared between GSC-suspicious vs. GSC-benign cohorts, as well as between malignant and benign nodules. The diagnostic performance of the GSC was compared between TIRADS 5 and TIRADS
Fields of Study & Subjects
Thyroid Cancer Diagnosis and Treatment
Thyroid Disorders and Treatments
Genomics and Rare Diseases
Publication details
- Journal / source
- Journal of the American Society of Cytopathology
- Publisher
- Elsevier BV
- Volume
- 15
- Issue
- 3
- Pages
- 207–213
- Publication date
- 12 January 2026
- Language
- EN