Commentary on “detoxification of deoxynivalenol by pathogen-inducible tau-class glutathione transferases from wheat”
Abstract
We found the article “Detoxification of deoxynivalenol (DON) by pathogen-tau-class glutathione transferases from wheat” by (1) engaging. This study enhances knowledge of defense systems against Fusarium graminearum demonstrating that multiple wheat tau-class glutathione transferases (GSTs) facilitate the conjugation of DON (deoxynivalenol) to generate DON-10-GSH and DON-13-GSH. The detailed structural elucidation of TaGST-10 (crystal structure of a wheat GST) bound to DON-13-GSH offers a mechanistic understanding of substrate orientation within the enzyme active site.
Fields of Study & Subjects
Glutathione Transferases and Polymorphisms
Mycotoxins in Agriculture and Food
Redox biology and oxidative stress
Publication details
- Journal / source
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Volume
- 302
- Issue
- 2
- Pages
- 111138–111138
- Publication date
- 21 January 2026
- Language
- EN