Catalytic and structural comparisons of linoleate dioxygenases and their cytochrome P450 companions with enzymes of the cyclooxygenase cascade
Abstract
by different mechanisms, but the presentation of the oxygen-oxygen bonds to the metal centers might be crucial. The AF2 models illustrate the structural, catalytical, and evolutionary relationships between COX and microbiological DOX with CYP companions in unprecedented details, which reveal multiple amino acids of potential catalytic significance for future research.
Fields of Study & Subjects
Metal-Catalyzed Oxygenation Mechanisms
Enzyme Structure and Function
Pharmacogenetics and Drug Metabolism
Publication details
- Journal / source
- Journal of Biological Chemistry
- Volume
- 302
- Issue
- 4
- Pages
- 111263–111263
- Publication date
- 7 February 2026
- Language
- EN