Targeting EphA2 under DNA damage causes mitotic bypass via p21 induction
Abstract
in interphase. Notably, p21 upregulation following EphA2 knockdown was observed specifically in cervical cancer cell lines. Finally, ADR-induced suppression of cell proliferation was further enhanced by EphA2 knockdown and partially reversed by p21 knockdown. In conclusion, EphA2 suppression induces p21-dependent mitotic bypass and tetraploidization, leading to reduced cell proliferation. EphA2 upregulation following DNA damage may be pro-tumorigenic by maintaining G2 arrest to keep DNA damage at tolerable levels. These findings provide a rationale for combining EphA2 inhibition with DNA-damaging agents in certain cancer types.
Fields of Study & Subjects
Cancer-related Molecular Pathways
DNA Repair Mechanisms
Microtubule and mitosis dynamics
Publication details
- Journal / source
- Journal of Biological Chemistry
- Volume
- 302
- Issue
- 3
- Pages
- 111271–111271
- Publication date
- 6 February 2026
- Language
- EN