Carotid perivascular adipose tissue attenuation predicts stroke and TIA in symptomatic carotid artery disease patients

Journal of cardiovascular computed tomography 2026 Open access

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Authors: Juul Bierens, Nora Jerkovic, Alida A. Postma, Daniel Bos, Pim A. de Jong, P. Nederkoorn, W. Mess, L. Saba, Luc J.M. Smits, Robert J. van Oostenbrugge, M. Eline Kooi
DOI: 10.1016/j.jcct.2025.12.009
Cited by: 1
References: 29

Abstract

BACKGROUND: Vascular inflammation is a key aspect of plaque vulnerability. Cross-sectional studies suggest that increased carotid perivascular adipose tissue (PVAT) attenuation on CTA, which is thought to reflect vascular inflammation, is associated with stroke. OBJECTIVES: We investigated the predictive value of carotid PVAT attenuation for ischemic stroke and TIA in a longitudinal study of symptomatic patients with carotid plaque. METHODS: We included patients with recent TIA or stroke and a ≥2 ​mm carotid plaque with

Fields of Study & Subjects

Cardiovascular Disease and Adiposity Cerebrovascular and Carotid Artery Diseases Adipokines Inflammation and Metabolic Diseases

Publication details

Journal / source
Journal of cardiovascular computed tomography
Publisher
Elsevier BV
Volume
20
Issue
2
Pages
140–147
Publication date
9 January 2026
Language
EN