Diuretic Resistance Risk and the Efficacy of Natriuresis-Guided Diuretic Therapy in Acute Heart Failure

JACC Heart Failure 2026 Open access

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Authors: Lara E.E.C. Zonneveld, Ambarish Pandey, Iris E. Beldhuis, Peter van der Meer, Jenifer E. Coster, Wybe Nieuwland, Joan C. Trullas, Dirk J. van Veldhuisen, Adriaan A. Voors, Kevin Damman, Jozine M. ter Maaten
DOI: 10.1016/j.jchf.2026.103017
Cited by: 2
References: 27

Abstract

BACKGROUND: Diuretic resistance (DR) is common in acute decompensated heart failure (ADHF) and is associated with residual congestion and poor prognosis. It remains unknown whether DR affects the beneficial effects of natriuresis-guided therapy. OBJECTIVES: This study aims to evaluate the efficacy of natriuresis-guided therapy in ADHF patients at risk of DR, as assessed by the BAN-ADHF (blood urea nitrogen, creatinine, natriuretic peptide levels, atrial fibrillation, diastolic blood pressure, hypertension and home diuretic, and heart failure hospitalization) score. METHODS: This post hoc analysis of the PUSH-AHF (Pragmatic Urinary Sodium AlgoritHm in Acute Heart Failure) trial stratified patients across DR risk groups using the previously validated BAN-ADHF score (

Fields of Study & Subjects

Heart Failure Treatment and Management Cardiovascular Function and Risk Factors Atrial Fibrillation Management and Outcomes

Publication details

Journal / source
JACC Heart Failure
Publisher
Elsevier BV
Volume
14
Issue
7
Pages
103017–103017
Publication date
27 March 2026
Language
EN