Fractional Flow Reserve–Guided Renal Artery Stenting in Renovascular Hypertension

JACC: Cardiovascular Interventions 2026 Open access

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Authors: Yuxi Li, Rujie Zheng, Xu Liu, Jingang Zheng, Chengzhi Lu, Fangfang Fan, Fude Zhou, Jianxing Qiu, Zhiyong Lin, Shuduo Zhou, Zhihao Liu, Shengcong Liu
+17 more Tieci Yi, Long Zhang, Haoyu Weng, Beining Wang, Yuxi Chang, Hui Zhou, Dengfeng Ma, Zhi Jia, Xiang Li, Renqiang Yang, Dongmei Shi, Hui Chen, Li Xu, Cun Liu, Kazuomi Kario, Yan Zhang, Jianping Li
DOI: 10.1016/j.jcin.2026.05.019
Cited by: 1
References: 24

Abstract

BACKGROUND: Whether fractional flow reserve (FFR)-guided revascularization improves outcomes in atherosclerotic renal artery stenosis (ARAS) remains uncertain. OBJECTIVES: This study will evaluate whether the benefit of FFR-guided stenting sustained at 1 year including renal outcomes. METHODS: FAIR pilot is an investigator-initiated, multicentre, open-label trial with blinded endpoint adjudication. Adults with ARAS were randomized 1:1 to FFR-guided vs angiography-guided groups. Stenting was performed in the FFR-guided group when FFR

Fields of Study & Subjects

Renal and Vascular Pathologies Abdominal vascular conditions and treatments Peripheral Artery Disease Management

Publication details

Journal / source
JACC: Cardiovascular Interventions
Publisher
Elsevier BV
Volume
19
Issue
13
Pages
1796–1807
Publication date
1 July 2026
Language
EN