Dietary Stearic Acid Accelerates Intestinal Tumorigenesis via Fatty Acid-binding Protein 5 Without Promoting Obesity

Cellular and Molecular Gastroenterology and Hepatology 2026 Open access

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Authors: Kazuaki Nakata, Seiga Komiyama, Keisuke Sekine, Motoyoshi Nagai, Takuma Okawa, Wakana Ohashi, Kenta Nakano, Tadashi Okamura, Takuma Kozono, Nobuyuki Takemura, Kazuhiko Yamada, Norihiro Kokudo
+3 more Taeko Dohi, Koji Hase, Yuki I. Kawamura
DOI: 10.1016/j.jcmgh.2026.101740
Cited by: 1
References: 53

Abstract

BACKGROUND & AIMS: Dietary fat increases the risk of intestinal cancer, but the effect of the fatty acid composition on tumorigenesis is unclear. The aim of this study is to investigate the impact of diets with different fatty acids on carcinogenesis in the intestine. METHODS: mice and an azoxymethane- and a dextran sulfate sodium-induced colorectal cancer (CRC) mouse model were used to examine the effects of different dietary fatty acids on CRC development. Fatty acid-binding protein 5 (FABP5) knockout mice and SBFI-26, an inhibitor of FABP5, were used to assess its contribution. RESULTS: cells was increased by SA-rich HFD feeding. FABP5 inhibition suppressed SA-induced epithelial cell proliferation, Paneth cell differentiation, and tumorigenesis. CONCLUSIONS: Dietary SA can promote CRC via FABP5 without promoting obesity.

Fields of Study & Subjects

Peroxisome Proliferator-Activated Receptors Fatty Acid Research and Health Amino Acid Enzymes and Metabolism

Publication details

Journal / source
Cellular and Molecular Gastroenterology and Hepatology
Publisher
Elsevier BV
Volume
20
Issue
5
Pages
101740–101740
Publication date
1 January 2026
Language
EN