Gas chromatography mass spectrometry based pharmacometabolomic assessment of formulation-dependent metabolic responses of levetiracetam

This study applied a GC–MS–based pharmacometabolomic approach to investigate formulation-dependent bioavailability and systemic metabolic responses following levetiracetam administration. Plasma samples from rabbits were analyzed after receiving three different formulations: a control formulation in which levetiracetam was mixed with deionized water, a multithick formulation prepared with an 8% modified maize starch thickener, and a thicken-up clear (TUC) formulation prepared with 3.6% xanthan gum thickener. Although dissolution profiles varied substantially among these formulations, Likewise, total levetiracetam exposure, represented by AUC, did not differ significantly among groups (p