Successful treatment of poison ivy dermatitis with upadacitinib

Allergic contact dermatitis (ACD), including Toxicodendron contact dermatitis (TCD) from poison ivy, oak, and sumac, is a delayed hypersensitivity reaction to the catechol urushiol and commonly presents as an intensely pruritic papulovesicular eruption with potential for prolonged courses and more severe reactions upon re-exposure.1 Despite the prevalence of urushiol-containing plants in North America, current therapies are suboptimal. Topical and short-term oral corticosteroids are often inadequate for a complete clinical response, while long-term oral steroids are associated with numerous adverse effects such as weight gain and mood changes.