Cocaine-associated plasma cell orificial mucositis (CAPCOM): An emerging entity

JAAD Case Reports 2026 Open access

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Authors: Priya Patel Housley, Sophie Tillotson, Milbrey A. Parke, Kiran Motaparthi
DOI: 10.1016/j.jdcr.2026.04.020
Cited by: 1
References: 13

Abstract

Cocaine-associated plasma cell orificial mucositis (CAPCOM), an emerging entity of increasing significance given the widespread use of cocaine, has been described recently and is thought to be a hypersensitivity reaction to a novel unidentified allergen in cocaine.1 Cocaine, along with its frequent adulterant levamisole, can cause a spectrum of cutaneous and mucosal disorders that may clinically and serologically mimic antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), risking unnecessary immunosuppression.

Fields of Study & Subjects

Oral health in cancer treatment Forensic Toxicology and Drug Analysis Bone health and treatments

Publication details

Journal / source
JAAD Case Reports
Publisher
Elsevier BV
Volume
72
Pages
212–217
Publication date
21 April 2026
Language
EN