Development of a next-generation wound-healing scaffold integrating decellularized dermis with tailored mesenchymal stromal cell secretomes

Journal of Drug Delivery Science and Technology 2026 Open access

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Authors: Marta Cecilia Tosca, Simona Turi, Dmitry Lim, Angelo Modena, Edoardo Bertania, Elia Bari, Lorena Segale, Lorella Giovannelli, Ivana Miletto, Ilenia Rita Renzulli, Rossana Rossi, Pierluigi Mauri
+3 more Dario Di Silvestre, Giovanni Sesana, Maria Luisa Torre
DOI: 10.1016/j.jddst.2026.108673
Cited by: 1
References: 75

Abstract

Chronic wounds are difficult to treat due to impaired cell proliferation, persistent inflammation, and delayed tissue remodeling. To address these challenges, biologically active scaffolds were developed by combining human decellularized dermis, obtained from cadaveric donors, with a standardized, freeze-dried secretome derived from mesenchymal stromal cells (MSC). Dermis scaffolds were prepared using five decellularization protocols, resulting in acellular matrices (DNA content

Fields of Study & Subjects

Tissue Engineering and Regenerative Medicine Wound Healing and Treatments Mesenchymal stem cell research

Publication details

Journal / source
Journal of Drug Delivery Science and Technology
Publisher
Elsevier BV
Volume
125
Pages
108673–108673
Publication date
3 July 2026
Language
EN