Overview of clinical evaluation methods for the Soothing Efficacy of Cosmetics

This review summarizes the current types of stimuli relevant to human skin, the clinical test methods for evaluating soothing efficacy, and classifies indicators based on the mechanisms of soothing products against different irritant types, thereby providing a reference for the efficacy assessment of soothing products. Methods: Corresponding evaluation methods and indicators were selected based on the mechanisms of soothing efficacy, a systematic review of skin irritation types and their corresponding soothing evaluation metrics were followed by. Results: Various skin irritation types were summarized, including sensitive skin, slight mechanical damage, ultraviolet (UV) exposure, seasonal and temperature changes, acne or inflammatory skin diseases, intensive beauty procedures and medical treatment, occupational exposure, mosquito bites, etc. For these types of stimulation, corresponding recommendations for selecting soothing efficacy evaluation indicators were proposed. Conclusion: To enhance testing efficiency and result reliability, the selection of evaluation methods and indicators for soothing efficacy should be rationally based on the product's mechanism of action. This study provides a reference for the efficacy evaluation of soothing products.