Antioxidant activity of Hassawi rice and sprouted Hassawi rice and its effect on lipid peroxidation and liver enzyme in hyperlipidemic rats

This study aimed to evaluate the antioxidant capacity and cholesterol-lowering effects of Hassawi rice in an experimental model of hyperlipidemia. A total of 48 albino rats were used to compare Hassawi rice powder (HR) and sprouted Hassawi rice (SHR) at 5% and 10% dietary inclusion over 28 days. SHR, particularly at 10%, significantly improved liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP)reduced serum lipids, including triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C), decreased oxidative markers, nitric oxide/nitrite (NO) and thiobarbituric acid reactive substances (TBARS), and elevated high-density lipoprotein cholesterol (HDL–C), superoxide dismutase (SOD), and reduced glutathione (GSH). SHR was more effective than HRP and the standard drug fenofibrate. Histological analysis showed substantial restoration of liver and heart architecture. These findings demonstrate SHR has strong antioxidants and anti-hyperlipidemic properties, highlighting its potential as a dietary intervention for oxidative stress-related disorders such as hyperlipidemia.