No distinct estrogenic or androgenic activity was observed in Korean Red Ginseng metabolites prepared using a S9 system

Journal of Ginseng Research 2026 Open access

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Authors: NamKyu Lee, YiSi Yang, DeYu Tian, Sun Hee Hyun, Youn Ji Lee, Youn Ji Lee, YoungJoo Lee, YoungJoo Lee
DOI: 10.1016/j.jgr.2026.100989
Cited by: 0
References: 23

Abstract

We determined whether Korean Red Ginseng (KRG) extract and ginsenosides (Rb1, Rg1, or Rg3) have estrogen receptor-mediated or androgen receptor-mediated activities using OECD TG455/458 assays with S9 metabolic activation. They did not elicit both hormonal receptor-mediated responses. KRG extract and ginsenosides do not have male and female sex hormone-like activity.

Fields of Study & Subjects

Ginseng Biological Effects and Applications Effects and risks of endocrine disrupting chemicals Estrogen and related hormone effects

Publication details

Journal / source
Journal of Ginseng Research
Volume
50
Issue
3
Pages
100989–100989
Publication date
30 January 2026
Language
EN