Incidence and implications of abstinence-induced recompensation in alcohol-related cirrhosis

Journal of Hepatology 2026 Open access

Read full text
Authors: Benedikt Hofer, M. Tonon, Laura Buttler, Joana Camões Neves, Queralt Herms, Enrico Pompili, Mina Ignat, Sophie Métivier, Susana Rodrigues, Daniel Gutmann, Jesús Donate, Jimmy Che‐To Lai
+36 more Ana Clemente Sánchez, Alba Jiménez-Masip, Josune Cabello, Charlotte Bouzbib, Henrik Karbannek, Jan Embacher, Thomas Sorz, Lukas Parandian, Antonio Accetta, Roberta Gagliardi, Marie Griemsmann, Jordi Gratacós-Ginès, Mattias Mandorfer, Guadalupe Garcia-Tsao, Douglas A. Simonetto, Georg Semmler, Alexander Zipprich, Marika Rudler, Jonel Trebicka, Genescà Joan, Rafael Bañares, Terry Cheuk-Fung Yip, L. Tellez, Emmanuel Tsochatzis, Annalisa Berzigotti, Hélène Larrue, Horia Stefanescu, P Caraceni, Elisa Pose, D A A Costa, Benjamin Maasoumy, Salvatore Piano, Thomas Reiberger, Michael Trauner, Andreas Stallmach, Agustín Albillos
DOI: 10.1016/j.jhep.2026.01.007
Cited by: 13
References: 27

Abstract

BACKGROUND & AIMS: Alcohol abstinence enables hepatic recompensation in patients with decompensated alcohol-related cirrhosis. This study investigated the incidence, predictors, and impact of abstinence-induced recompensation. METHODS: This multicentre study included patients with decompensated alcohol-related cirrhosis recruited at the time of abstinence up to December 2022. Recompensation was defined by Baveno VII criteria: (i) sustained abstinence (≥3 months), (ii) resolution of ascites and hepatic encephalopathy off therapy, (iii) absence of variceal bleeding for 1 year, and (iv) restored liver function (Child-Pugh A or MELD

Fields of Study & Subjects

Alcohol Consumption and Health Effects Liver Disease and Transplantation Alcoholism and Thiamine Deficiency

Publication details

Journal / source
Journal of Hepatology
Publisher
Elsevier BV
Volume
84
Issue
6
Pages
1077–1088
Publication date
22 January 2026
Language
EN