Macrophage-derived cathepsin B disrupts intestinal tight junctions through occludin degradation and promotes alcohol-associated liver disease

Journal of Hepatology 2026 Open access

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Authors: Marcos F. Fondevila, Henriette Kreimeyer, Cynthia L. Hsu, Joaquin Tamargo‐Azpilicueta, Le Day, Marina Gritsenko, Kwame Attah, Noemí Cabré, Aenne Harberts, Fernanda Raya Tonetti, Yongqiang Yang, Tomoo Yamazaki
+19 more David Schöler, Álvaro Eguileor, Colleen Blasio, Abraham S. Meijnikman, Xinlian Zhang, Ricard Garcia-Carbonell, Vivian Hook, Enchen Zhou, Zhaoli Sun, Jon Jacobs, Jerrold R. Turner, Cristina Llorente, AlcHepNet Investigators, Christopher K. Glass, Peter Stärkel, Thomas Reinheckel, Irene Diaz-Moreno, David J. Gonzalez, Bernd Schnabl
DOI: 10.1016/j.jhep.2026.01.013
Cited by: 5
References: 69

Fields of Study & Subjects

Barrier Structure and Function Studies Alcohol Consumption and Health Effects Liver Disease and Transplantation

Publication details

Journal / source
Journal of Hepatology
Publisher
Elsevier BV
Volume
84
Issue
6
Pages
1045–1061
Publication date
6 February 2026
Language
EN