Update in clinical science: MASLD in children and adolescents
Abstract
Paediatric metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasingly common liver disease, with an estimated global prevalence of up to 7.5% and growing concern regarding hepatic and extrahepatic complications even in early life. In this paper, we review recent advances in epidemiology, genetics, early-life risk factors, natural history and comorbidities, focusing on emerging data published in the last 3 years. We also outline a practical approach to the management of MASLD in children, integrating newly developed non-invasive tests. Lastly, we highlight key research questions to be studied in the coming years.
Fields of Study & Subjects
Liver Disease Diagnosis and Treatment
Liver Disease and Transplantation
Liver Diseases and Immunity
Publication details
- Journal / source
- Journal of Hepatology
- Publisher
- Elsevier BV
- Volume
- 84
- Issue
- 6
- Pages
- 1164–1177
- Publication date
- 21 February 2026
- Language
- EN