Factors associated with protection from MASLD in type 2 diabetes: A prospective study integrating longitudinal MRI/MRE and stable isotope tracing

JHEP Reports 2026 Open access

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Authors: Federica Tavaglione, Veeral H. Ajmera, Luis Antonio Díaz, Kelvin Li, Egbert V. Madamba, Ricki Bettencourt, Lisa Richards, Marc K. Hellerstein, Rohit Seth Loomba
DOI: 10.1016/j.jhepr.2026.101733
Cited by: 0
References: 33

Abstract

Background & Aims Type 2 diabetes is one of the strongest risk factors for the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). In this study, we aimed to identify factors associated with protection from MASLD in a prospective cohort of individuals with type 2 diabetes. Methods This prospective study included 148 individuals with type 2 diabetes who underwent advanced liver phenotyping using MRI and MRE techniques at baseline and 2-year follow-up. Protection from MASLD was defined as the absence of hepatic steatosis (MRI-proton density fat fraction

Fields of Study & Subjects

Liver Disease Diagnosis and Treatment Advanced MRI Techniques and Applications Diet and metabolism studies

Publication details

Journal / source
JHEP Reports
Volume
8
Issue
3
Pages
101733–101733
Publication date
8 January 2026
Language
EN