Prognostic implications of tumour number in intrahepatic cholangiocarcinoma

JHEP Reports 2026 Open access

Read full text
Authors: Brandon Lok-Hang Chan, Yan Li, YoungJae Kim, Alex C. F. Wong, Dorothy Cheuk-Yan Yiu, Landon Long Chan, Cheuk Man Chu, Changhoon Yoo, Hui‐Chuan Sun, Stephen Lam Chan
DOI: 10.1016/j.jhepr.2026.101756
Cited by: 0
References: 30

Abstract

Background & Aims: edition of the AJCC staging system. However, tumour multiplicity is frequently associated with poor prognosis in ICC. We aimed to elucidate the prognosis of ICC with multiple tumours and the impact of the number of liver tumours on survival. Methods: Patients who were diagnosed with ICC with solitary liver tumours or multiple liver tumours between May 2008 and December 2019 at three tertiary referral centres in Hong Kong, Seoul and Shanghai were enrolled. Kaplan-Meier analyses and multivariable Cox proportional hazards models were used to analyse the association between tumour multiplicity and overall survival (OS). Results:

Fields of Study & Subjects

Cholangiocarcinoma and Gallbladder Cancer Studies Pediatric Hepatobiliary Diseases and Treatments Hepatocellular Carcinoma Treatment and Prognosis

Publication details

Journal / source
JHEP Reports
Volume
8
Issue
4
Pages
101756–101756
Publication date
30 January 2026
Language
EN