Multiomics and multi-region spatial transcriptome analysis reveal cellular networks and pathways associated with HCC recurrence

JHEP Reports 2026 Open access

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Authors: Veerabrahma Pratap Seshachalam, Ita Novita Sari, K.C. Toh, Prativa Majee, Shay Lee Chong, Karthik Sekar, Aziz Aiderus, Khaireen Idzham, Ong Y. Qi, Li Yen Chong, Matias Caldez, Raghuvaran Shanmugam
+26 more Dorcas H.H. Ying, Esmond Lee, Jiaying Toh, Wu Lele, Jia Y.J. Lee, Guorui Zhong, Sin Chi Chew, Gao B. Chen, Lingyan Wu, Alexander Y. F. Chung, PC Cheow, Juinn Huar Kam, Alfred WC Kow, Wei Q. Leow, Nagalakshmi Jegannathan, Kaina Chen, Chairat Bunchaliew, Vanessa H. de Villa, Peng S. Koh, Glenn Kunnath Bonney, Brian K.P. GOH, Wai Leong Tam, Lit‐Hsin Loo, Joe Yeong, Vinay Tergaonkar, Pierce K. H. Chow
DOI: 10.1016/j.jhepr.2026.101790
Cited by: 1
References: 56

Abstract

BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) exhibits diverse aetiologies and molecular heterogeneity, with a median 5-year overall survival of

Fields of Study & Subjects

Single-cell and spatial transcriptomics Cancer-related Molecular Pathways Cell Image Analysis Techniques

Publication details

Journal / source
JHEP Reports
Publisher
Elsevier BV
Volume
8
Issue
5
Pages
101790–101790
Publication date
19 February 2026
Language
EN