Enhancing biliary protection via HOPE: Beyond bile composition to cholangiocyte resilience
Abstract
We read with great interest the randomized controlled trial by Schliephake et al1. investigating the effects of hypothermic oxygenated machine perfusion (HOPE) on bile composition after liver transplantation. We commend the authors for their meticulous lipidomic and transcriptomic analysis, which provides robust evidence that HOPE significantly improves biliary lipid secretion and mitigates the intrahepatic accumulation of hydrophobic bile acids. While these findings mark a pivotal step in understanding machine perfusion’s benefits, we believe several nuances regarding the
Fields of Study & Subjects
Organ Transplantation Techniques and Outcomes
Liver physiology and pathology
Transplantation: Methods and Outcomes
Publication details
- Journal / source
- JHEP Reports
- Volume
- 8
- Issue
- 9
- Pages
- 101797–101797
- Publication date
- 27 February 2026
- Language
- EN