Frailty assessment and candidate optimization before cardiothoracic transplantation

JHLT Open 2026 Open access

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Authors: Antoine Premachandra, Jacob A. Klapper, Jonathan Messika, Maïra Gaillard, Martin Kloeckner, Kamrouz Ghadimi, Matthieu Reffienna, Krista Ingle, Kirti A. Magudia, Brandi Bottiger
DOI: 10.1016/j.jhlto.2026.100492
Cited by: 1
References: 58

Abstract

Frailty is an important syndrome in an aging thoracic transplant population, particularly in the context of end-stage cardiopulmonary disease. In this review, we discuss the core problem of lack of physiologic reserve in these patients and its relationship to perioperative outcomes, how to define and measure frailty in the context of heart and lung transplant and identify interventions to treat contributors to this clinical syndrome. We highlight the critical need in the transplant community to identify and treat these conditions prior to their transplantation and to prevent comorbidity and mortality.

Fields of Study & Subjects

Transplantation: Methods and Outcomes Frailty in Older Adults Cardiovascular Function and Risk Factors

Publication details

Journal / source
JHLT Open
Publisher
Elsevier BV
Volume
12
Pages
100492–100492
Publication date
18 January 2026
Language
EN