Drug-coated balloon treatment of in-stent restenosis in complex severe cardiac allograft vasculopathy

JHLT Open 2026 Open access

Read full text
Authors: Tolulope Popoola, Madhan Shanmugasundaram, Elizabeth Juneman, Deepak Acharya
DOI: 10.1016/j.jhlto.2026.100607
Cited by: 1
References: 15

Abstract

Cardiac allograft vasculopathy (CAV) is a leading cause of late graft failure with limited revascularization options and high rates of in-stent restenosis (ISR). This report details a 33-year-old heart transplant recipient with progressive CAV that underwent multiple prior revascularizations, including drug-eluting stents and coronary artery bypass grafting. He developed ISR of the right coronary artery stent, treated with paclitaxel drug-coated balloon (DCB) without further stenting. Follow-up at 3 and 9 months showed patent vessels without recurrent restenosis and preserved graft function. DCB may be a viable option for ISR in advanced CAV when additional stenting is undesirable. Larger studies are needed to define its long-term role.

Fields of Study & Subjects

Coronary Interventions and Diagnostics Cardiac pacing and defibrillation studies Cardiac Structural Anomalies and Repair

Publication details

Journal / source
JHLT Open
Publisher
Elsevier BV
Volume
13
Pages
100607–100607
Publication date
6 June 2026
Language
EN