ZNF750 safeguards upper hair follicle homeostasis to prevent inflammatory skin disease

Journal of Investigative Dermatology 2026 Open access

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Authors: Uyanga Batzorig, Grace Zhang, Chang Chun Yang, Ye Liu, Celia Fernández-Méndez, Samiksha Mahapatra, Jae‐Joong Kim, Neha Quadir, George L. Sen
DOI: 10.1016/j.jid.2026.04.010
Cited by: 1
References: 9

Abstract

ZNF750, a zinc-finger transcription factor, plays a pivotal role in promoting epidermal differentiation and barrier formation in murine and human skin (Butera et al, 2023; Schwartz et al, 2023; Sen et al, 2012). ZNF750 does this by transcriptionally activating genes coding for proteins involved in lipid processing/homeostasis and stratum corneum development. Sequence variations in ZNF750 have been linked to skin inflammatory diseases such as psoriasis and seborrheic-like dermatitis with a psoriasiform phenotype (Birnbaum et al, 2006; Yang et al, 2008).

Fields of Study & Subjects

Hair Growth and Disorders Skin and Cellular Biology Research Hidradenitis Suppurativa and Treatments

Publication details

Journal / source
Journal of Investigative Dermatology
Publisher
Elsevier BV
Volume
146
Issue
9
Pages
2618–2622.e3
Publication date
29 April 2026
Language
EN