Increased long-term mortality of patients with prosthetic joint infection after primary total hip arthroplasty – A large observational cohort study

Journal of Infection 2026 Open access

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Authors: Andreas Widmer, Nadine Imhasly, Christian Brand, Vilijam Zdravkovi, Adrian Spoerri, Kurt Schmidlin, Melanie Wicki, Martin Beck, Rami Sommerstein
DOI: 10.1016/j.jinf.2026.106689
Cited by: 3
References: 27

Abstract

OBJECTIVE: Evaluate long-term mortality and the role of causative pathogens in periprosthetic joint infection (PJI) following total hip arthroplasty (THA). METHODS: Retrospective nationwide cohort study of adults undergoing THA (2012-2022) using data from the Swiss Joint Registry, Center for Infection Prevention and civil registry. Primary outcome was up to 10-year survival with or without PJI. Adjusted hazard ratios (aHR) were estimated via Gompertz regression, controlling for sex, age, BMI, and ASA. Pathogen-specific mortality hazard was analyzed. RESULTS: Of 215,678 patients, 89,709 met inclusion criteria (51.3% women; median age 69 years). PJI occurred in 745 (0.8%) patients, 2 752 (3.1%) underwent aseptic revision. PJI was associated with increased mortality (aHR 2.15; 95% CI, 1.79-2.57; p

Fields of Study & Subjects

Orthopedic Infections and Treatments Total Knee Arthroplasty Outcomes Surgical site infection prevention

Publication details

Journal / source
Journal of Infection
Publisher
Elsevier BV
Volume
92
Issue
2
Pages
106689–106689
Publication date
12 January 2026
Language
EN