Predictors of mortality and therapeutic efficacy in carbapenem-resistant Acinetobacter baumannii bacteremia

Journal of Infection 2026 Open access

Read full text
Authors: Alessandro Russo, Sara Palma Gullì, Antonio Vena, Luigi Spadafora, Marco Bernardi, Silvia Corcione, Giancarlo Ceccarelli, Francesco Alessandri, Claudio Maria Mastroianni, Alessandra Oliva, Emmanuele Venanzi Rullo, Giuseppe Caviglia
+88 more Andrea Cortegiani, Mariachiara Ippolito, Giuseppe Nunnari, Francesco Di Gennaro, Annalisa Saracino, Ana Mariño, Bruno Cacopardo, Giusy Tiseo, Marco Falcone, Valentina Galfo, Chiara Iaria, Giuseppe Pipitone, Antonio Cascio, Sergio Carbonara, Laura Montemurro, Francesco Saverio Serino, Nicoletta Boffa, Marco Libanore, Francesco Giuseppe De Rosa, Alessia Mattei, Alessandra Calabresi, Mario Tumbarello, Lucia Fontanelli Šuleková, Carlo Pallotto, Pierluigi Brugnaro, R. Mascianà, Beatrice Tiri, Nicola Coppola, Giosuele Calabria, Alessandra Bandera, Andrea Lombardi, Paolo Vassalini, Novella Carannante, Vincenzo Scaglione, Marianna Meschiari, Omar Simonetti, Alessandra Mularoni, Fabrizio Bar, Riccardo Serraino, Cristina Mussini, Matteo Bassetti, Giuseppe Biondi-Zoccai, Francesca Serapide, Luisa Frallonardo, Luca Pipitò, Annamaria Cattelan, Ylenia Russotto, Saverio Nicolosi, Mario Pantaleoni, Diletta Testi, Giuseppe Vittorio De Socio, Debora Altobelli, Elena Momesso, Alessandro De Felice, Mario Alessio Guarano, Stefano Di Bella, Caterina Di Cecco, Antonella Gallicchio, Maddalena Peghin, Filippo Givone, Paolo Grossi, Luciano Caterini, Linda Erario, Mariano Corrado, Margherita Macera, Alfredo Kunkar, G. Nicolò, Alessandro Franzò, Giovanna De Candia, Francesco Cozzolino, Rosa Spinelli, Maria Di Stasi, Roberto Papale, Felicia Anna Spadavecchia, Daniela Tatò, Ivan Gentile, Adriana Boccuzzi, Simona Tuberga, Lorenzo Surace, Giuseppe Fiorentino, Stefano Cappanera, Emanuela Sensi, Marco Visicaro, Antonio Mastroianni, Michela Comi, Nicolò Presa, Nicholas Geremia, Alice Picciarella
DOI: 10.1016/j.jinf.2026.106742
Cited by: 5
References: 31

Abstract

OBJECTIVES: Bacteremia caused by carbapenem-resistant Acinetobacter baumannii (CRAB) is associated with high morbidity and mortality. The primary objective was to identify clinical and therapeutic factors associated with 14- and 30-day mortality following infection onset. METHODS: This was a prospective, observational, multicenter study conducted across 52 Italian centers. Over an 18-month period, adult hospitalized patients with CRAB bacteremia were enrolled. RESULTS: Among 398 patients with CRAB bacteremia, sources were mainly CVC-related or primary, with 14- and 30-day mortality rates of 22% and 27% respectively. Cox regression analysis identified male sex (p=0.006), and chronic kidney disease (p=0.016) as independent predictors of 14-day mortality, while colistin-containing regimen (p=0.014), and cefiderocol-containing-regimen (p

Fields of Study & Subjects

Antibiotic Resistance in Bacteria Antibiotics Pharmacokinetics and Efficacy Antibiotic Use and Resistance

Publication details

Journal / source
Journal of Infection
Publisher
Elsevier BV
Volume
92
Issue
5
Pages
106742–106742
Publication date
31 March 2026
Language
EN