Probiotics in the treatment of helicobacter pylori infection: A bibliometric analysis from 2001 to 2025

BACKGROUND: Helicobacter pylori (H. pylori) infection is widespread in about half of the world's population, and it has become a major public health problem. There are more and more probiotic studies on the management of H. pylori. This study uses bibliometric analysis to show the current pattern and development trend of research on H. pylori. METHODS: We collected the publications about H. pylori and probiotics from the Web of Science Core Collection(WoSCC), and the database was established until July 11th, 2025. We use MicrosoftExcel to organize a preliminary quantitative overview, CiteSpace and VOSviewer to visualize the writer network, keyword co-occurrence and organization distribution in more detail. RESULTS: This bibliometrics research contains 295 publications, all of which were published between 2001 and 2025. According to the analysis results, the number of papers in this field is on the rise, and China ranks first in the number of publications and citations. In this field, Helicobacter magazine ranks first in the number of publications and citations, Qinggu and Koga Kanghong are the most active researchers . The most frequently cited paper is "Effects of different probiotic preparations on the side effects related to the treatment of Helicobacter pylori: a parallel group, triple blind and placebo-controlled study". In recent years, the mechanism of probiotics in the treatment of H. pylori has been a research focus. CONCLUSIONS: Our study constitutes the first bibliometric analysis specifically dedicated to research at the intersection of H. pylori and probiotics. By comprehensively synthesizing the current landscape of probiotic research in H. pylori prevention and management, we have delineated the core research orientations and emerging frontiers in this domain. This work offers valuable empirical support to assist researchers in staying abreast of the latest advancements and accelerating the translational development of probiotics in H. pylori eradication strategies.