A two-sample test based on averaged Wilcoxon rank sums over interpoint distances

An important class of two-sample multivariate homogeneity tests is based on identifying differences between the distributions of interpoint distances. While generating distances from point clouds offers a straightforward and intuitive way for dimensionality reduction, it also introduces dependencies to the resulting distance samples. We propose a simple test based on Wilcoxon’s rank sum statistic for which we prove asymptotic normality under the null hypothesis and fixed alternatives under mild conditions on the underlying distributions of the point clouds. Furthermore, we show consistency of the test and derive a variance approximation that allows to construct a computationally feasible, distribution-free test with good finite sample performance. We apply the proposed test to case-control testing on microarray data in genetic studies, which is considered a notorious case for a high number of variables and low sample sizes.