The impact of a western diet with high salt on metabolic outcomes in male C57bl/6J mice

The Journal of Nutritional Physiology 2026 Open access

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Authors: Michael E. Ponte, John C. Prom, Pradeep Devkota, Sireesha Yerrathota, Mea Carradine, Larry Ha, E. Matthew Morris, Andrew J. Lutkewitte
DOI: 10.1016/j.jnphys.2026.100025
Cited by: 0
References: 47

Abstract

Abstract Objective The Western diet promotes obesity and metabolic disease by increasing caloric intake and systemic inflammation. The typical Western diet is high in saturated fats, sugars, and salt. In pre-clinical rodent studies, the “Western” diet (also called the high-fat high-sucrose diet (HFHS)) is high in saturated fats and sugars (typically sucrose) but low in salt (

Fields of Study & Subjects

Diet Metabolism and Disease Sodium Intake and Health Regulation of Appetite and Obesity

Publication details

Journal / source
The Journal of Nutritional Physiology
Volume
6
Pages
100025–100025
Publication date
19 April 2026
Language
EN