Creatine supplementation for preventing muscle atrophy in patients taking incretin-based pharmacotherapies: a perspective

The Journal of Nutritional Physiology 2026 Open access

Read full text
Authors: Felipe Ribeiro, Scott C. Forbes, Darren G. Candow, Pedro Perim, Chad Kerksick, Kelly Johnson, Antonio Herbert Lancha, Jose Reinaldo Cunha Santos A V Silva Neto
DOI: 10.1016/j.jnphys.2026.100028
Cited by: 1
References: 33

Abstract

Skeletal muscle is a central regulator of systemic metabolism, accounting for nearly half of total body mass and playing a critical role in glucose disposal, lipid oxidation, amino acid turnover, and overall energy balance (Baskin et al., 2015; Rolfe & Brown, 1997). Beyond its mechanical function, muscle acts as an endocrine organ through the secretion of myokines that coordinate communication with the brain, liver, heart, and adipose tissue (Ribeiro et al., 2025). Accordingly, both the quantity and quality of skeletal muscle are fundamental determinants of metabolic health and long-term physiological resilience (De Santana et al., 2019).

Fields of Study & Subjects

Muscle metabolism and nutrition Nutrition and Health in Aging Muscle Physiology and Disorders

Publication details

Journal / source
The Journal of Nutritional Physiology
Publisher
Elsevier BV
Pages
100028–100028
Publication date
1 April 2026
Language
EN