(Poly)phenol and methylxanthine metabolites and their association with cognitive and cardiometabolic health in older people

The Journal of Nutritional Biochemistry 2026 Open access

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Authors: Yong Li, Mélanie Le Sayec, Yifan Xu, Anne Katrine Bergland, Khadija Nasralla Khalifa, Chiara de Lucia, Dag Aarsland, Rachel Gibson, Ana Rodriguez‐Mateos
DOI: 10.1016/j.jnutbio.2026.110300
Cited by: 0
References: 66

Abstract

Dietary (poly)phenols and methylxanthines may help lower the risk of developing neurodegenerative diseases. However, the relationship between (poly)phenols and methylxanthines and age-related cognitive impairment has not been fully explored, in particular (poly)phenol-rich diets using biomarkers. A cross-sectional analysis was conducted on 202 participants aged 60 - 80 diagnosed with mild cognitive impairment (MCI) or two or more cardiometabolic disorders (CMD). The associations between metabolic signature/metabolites, cognition, and cardiometabolic risk were assessed using linear models, adjusted for covariates and multiple testing (FDR

Fields of Study & Subjects

Phytochemicals and Antioxidant Activities Dementia and Cognitive Impairment Research Nutritional Studies and Diet

Publication details

Journal / source
The Journal of Nutritional Biochemistry
Volume
153
Pages
110300–110300
Publication date
3 February 2026
Language
EN