Closure of atrial septal defect normalizes left and right ventricular hemodynamic forces in children and adolescents
Abstract
BACKGROUND: Atrial septal defect (ASD) is one of the most common congenital heart defects and leads to chronic right ventricular (RV) volume loading, which may progress to heart failure if untreated. Surgical or transcatheter closure unloads the RV and improves hemodynamics, but the impact on intraventricular hemodynamic forces (HDF) remains unclear. Here, we evaluated the effects of ASD closure on biventricular HDF. METHODS: Cardiac magnetic resonance imaging was performed at 1.5T on 21 patients and 11 sex- and age-matched healthy controls. Whole-heart 4D flow and cine images in standard views were acquired and used to compute HDF using custom software (Segment). Paired analysis was used to compare HDF pre-/post ASD closure. RESULTS: At baseline, patients showed aberrant RV HDF in both longitudinal and transverse directions (p
Fields of Study & Subjects
Cardiovascular Function and Risk Factors
Congenital Heart Disease Studies
Cardiovascular and Diving-Related Complications
Publication details
- Journal / source
- Journal of Cardiovascular Magnetic Resonance
- Publisher
- Elsevier BV
- Volume
- 28
- Issue
- 1
- Pages
- 102704–102704
- Publication date
- 1 January 2026
- Language
- EN