Blastocoele re-expansion at time of frozen embryo transfer affects clinical outcome following vitrification and warming

Journal of Gynecology Obstetrics and Human Reproduction 2026 Open access

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Authors: Katrina Hickey, Humaira Niazi, Zaynab Malik, Abirami Kirubarajan, Stacy Deniz, Shilpa Amin, Megan Freebury Karnis, Michael J. Neal, Mehrnoosh Faghih
DOI: 10.1016/j.jogoh.2026.103196
Cited by: 0
References: 22

Abstract

INTRODUCTION: While previous studies have correlated blastocyst expansion with pregnancy, there is limited evidence regarding post-warming characteristics and specifically the capability of the vitrified and warmed blastocyst to re-expand fully to the pre-vitrification state. OBJECTIVE: This study aimed to examine the effect of blastocyst re-expansion on clinical pregnancy rates (CPRs) in frozen embryo transfer (FET) cycles. MATERIALS AND METHODS: In this retrospective cohort, FET patients were stratified into "collapsed" and "re-expanded" groups and further categorized into good (≥ 3BB) or low (

Fields of Study & Subjects

Reproductive Biology and Fertility Ovarian function and disorders Reproductive Health and Technologies

Publication details

Journal / source
Journal of Gynecology Obstetrics and Human Reproduction
Publisher
Elsevier BV
Volume
55
Issue
7
Pages
103196–103196
Publication date
24 April 2026
Language
EN