Synthesis of chiral P,S ferrocenyl ligands for catalyst heterogenization and testing in the homogeneous asymmetric hydrogenation of acetophenone
Abstract
Racemic and chiral P,S ferrocenyl ligands bearing a phenol function for further catalyst grafting were synthesized and fully characterized (multinuclear NMR, high-resolution MS, X-ray diffraction). Analogs bearing a methoxy group instead of OH (anisole instead of phenol) were also synthesized to mimic the expected ether formation after grafting in order to assess the ether group influence on catalysis. Good activity and enantioselectivity (up to 78%), similar to non-functionalized ligands, were obtained in the asymmetric hydrogenation of acetophenone. The base concentration appears to have major influence on both activity and enantioselectivity.
Fields of Study & Subjects
Asymmetric Hydrogenation and Catalysis
Asymmetric Synthesis and Catalysis
N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
Publication details
- Journal / source
- Journal of Organometallic Chemistry
- Volume
- 1048
- Pages
- 124049–124049
- Publication date
- 31 January 2026
- Language
- EN