Definitive surgery for Hirschsprung Disease between 3 and 12 months achieves best outcomes: A systematic review with meta-analysis

Journal of Pediatric Surgery 2026 Open access

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Authors: Oliver Sowulewski, Julia Leszkowicz, Marlena Sakowska, Piotr Spychalski, Agnieszka Szlagatys‐Sidorkiewicz
DOI: 10.1016/j.jpedsurg.2026.163039
Cited by: 1
References: 22

Abstract

INTRODUCTION: Optimal age for definitive pull-through in Hirschsprung disease (HD) is debated. Both early and delayed interventions may influence short- and long-term outcomes, but current guidelines do not provide a clear recommendation. METHODS: A systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Nineteen studies published between 1998 and 2025, including 3980 pediatric patients with HD undergoing definitive pull-through surgery, were included. Age at surgery was stratified using predefined thresholds (neonatal,

Fields of Study & Subjects

Congenital gastrointestinal and neural anomalies Craniofacial Disorders and Treatments Congenital Ear and Nasal Anomalies

Publication details

Journal / source
Journal of Pediatric Surgery
Publisher
Elsevier BV
Volume
61
Issue
6
Pages
163039–163039
Publication date
3 March 2026
Language
EN