Discovery of a pyridine-piperazine-based small molecule that enhances the activity of peptidase neurolysin

Journal of Pharmacology and Experimental Therapeutics 2026 Open access

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Authors: Heba ElSayed ElZorkany, Haya Kandil, Srinidhi Jayaraman, Asmaa Aly, Shiva Hadi Esfahani, Dhavalkumar Patel, Dennis Dannecker, Monika Maciąg, Alyssa Paul, Kaitlin Lowran, Shikha Kumari, Samik Bose
+7 more David A. Ostrov, Colin G. Wu, Alex Dickson, Thomas J. Abbruscato, Paul C. Trippier, Benjamin J. Orlando, Vardan T. Karamyan
DOI: 10.1016/j.jpet.2026.103827
Cited by: 1
References: 71

Fields of Study & Subjects

Peptidase Inhibition and Analysis Neuropeptides and Animal Physiology Protein Hydrolysis and Bioactive Peptides

Publication details

Journal / source
Journal of Pharmacology and Experimental Therapeutics
Publisher
Elsevier BV
Volume
393
Issue
3
Pages
103827–103827
Publication date
3 February 2026
Language
EN