Multiomics and experimental validation reveal theophylline’s mechanism targeting IL1A/ACTB/TLR4 and identify synergistic drugs in hepatocellular carcinoma

Yuxiang Gao; Wei Chen; Paul Zarogoulidis; Murali M. Yallapu; Miloš Nikolić; Deep K Vaishnani; Jianjian Zheng; Nikola Nedeljkovic; Kexin Ye; Yong Guo; Qiyu Xu

doi:10.1016/j.jpet.2026.103836

Multiomics and experimental validation reveal theophylline’s mechanism targeting IL1A/ACTB/TLR4 and identify synergistic drugs in hepatocellular carcinoma

Journal of Pharmacology and Experimental Therapeutics 2026

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Authors: Yuxiang Gao, Wei Chen, Paul Zarogoulidis, Murali M. Yallapu, Miloš Nikolić, Deep K Vaishnani, Jianjian Zheng, Nikola Nedeljkovic, Kexin Ye, Yong Guo, Qiyu Xu

DOI: 10.1016/j.jpet.2026.103836

Cited by: 6

References: 46

Fields of Study & Subjects

Ferroptosis and cancer prognosis Immune cells in cancer Computational Drug Discovery Methods

Publication details

Journal / source: Journal of Pharmacology and Experimental Therapeutics
Publisher: Elsevier BV
Volume: 393
Issue: 3
Pages: 103836–103836
Publication date: 10 February 2026
Language: EN

References 46