GSH-triggered release of anabasine in mitochondria for synergistic chemotherapy assisted by OATP transportation

Journal of Pharmaceutical Analysis 2026 Open access

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Authors: Miao Zhang, Ling-Li Wang, Si-Ling Chen, Yanping Liu, Ming-Hua Zheng, Jing-Yi Jin
DOI: 10.1016/j.jpha.2026.101565
Cited by: 0
References: 4

Abstract

• A GSH-triggered prodrug targeting tumor cell mitochondria via OATP-mediated uptake. • Release of a parent drug through an GSH-triggered S N Ar mechanism. • Translation of a nicotinic acetylcholine receptor to an antitumor drug. • Anabasine in mitochondria and induce a synergistic ferritinophagy and apoptosis.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Nanoparticle-Based Drug Delivery Synthesis and biological activity

Publication details

Journal / source
Journal of Pharmaceutical Analysis
Volume
16
Issue
6
Pages
101565–101565
Publication date
28 January 2026
Language
EN