TTP/UiO-66-NH2 hybrid: a high-performance ratiometric fluorescent probe for the selective and rapid detection of chlortetracycline at a wide pH range.

The integration of covalent organic frameworks (COFs) and metal-organic frameworks (MOFs) into hybrid materials capitalizes on the advantageous properties of both classes of materials, particularly addressing the aggregation-caused quenching effect associated with COFs to enhance their luminescence. Furthermore, COF/MOF hybrid materials represent a promising approach for the development of ratiometric fluorescent methods. In this study, we synthesized a hybrid material, TTP/UiO-66-NH 2 , characterized by the robust attachment of TTP COF to the surface of UiO-66-NH 2 MOF via a Schiff base reaction. The TTP/UiO-66-NH 2 hybrid material combined the strengths of both components, exhibiting remarkable stability, a broad pH tolerance, and excellent dual-emission fluorescence. Additionally, as a dual-emission fluorescent probe, TTP/UiO-66-NH 2 effectively identified chlorotetracycline in three animal-derived food samples. This fluorescent probe demonstrated high selectivity, strong specificity, and superior anti-interference capabilities, along with a rapid response time of 25 s, a wide pH range (3.0–9.0), a high recovery rate (89.73–112.05%), an extensive linear range (0–220 μmol/L), and low detection limits (0.089–0.095 μmol/L). This research provided a novel fluorescent probe for the detection of chlorotetracycline and opened avenues for further applications.