Comment on “Exercise-induced extracellular vesicles delay tumor development by igniting inflammation in an immunologically cold triple-negative breast cancer mouse model”

A recent study published in the Journal of Sport and Health Science provides the first systematic evidence that exercise can drive the immune system to convert cold triple-negative breast cancer (TNBC) tumors into hot tumors.Mlynska and colleagues 1 administered exercise-induced extracellular vesicles (EVs) isolated from healthy mouse plasma to 2 mouse models of TNBC: 4T1 and EO771.Results showed that pretumor implantation administration of exercise-induced EVs significantly inhibited tumor growth in both models.Tumor volumes in the EVs group were markedly smaller than in the control group, accompanied by a significant increase in the number of cluster of differentiation 8 T lymphocytes (CD8 + T cells) within the tumors.The researchers innovatively designed 3 intervention protocols: preventive, therapeutic, and continuous intervention to systematically explore the effects of exercise-induced exosomes at different stages of tumor development.This provides crucial experimental evidence for defining their clinical applications in cancer prevention and treatment.This study holds significant implications for the field of exercise oncology.Numerous studies have demonstrated that aerobic exercise exerts beneficial effects at different stages of cancer progression.Zhang et al. 2 conducted a 32-year follow-up study involving 231,067 individuals.Their results showed that engaging in approximately 17 h of moderate physical activity per week for 30 years was sufficient to achieve the optimal effect of reducing the risk of digestive system cancers.Phelps et al. 3 confirmed that exercise stimulates the one-carbon metabolism of the gut microbiota, elevating the level of the metabolite formate, and thereby enhances the efficacy of Peer review under responsibility of Shanghai University of Sport.