Increased Susceptibility to Long-Term Complications in Leukemia Survivors Who Received Hematopoietic Stem Cell Transplantation During Adolescence

Transplantation and Cellular Therapy 2026 Open access

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Authors: Léna Pessarossi, Marilyne Poirée, Jean‐Hugues Dalle, Sandrine Visentin, Carine Domenech, Cécile Renard, Cécile Pochon, André Baruchel, Mony Fahd, Virginie Gandemer, Charlotte Jubert, Stéphane Ducassou
+14 more Catherine Paillard, Laura Olivier‐Gougenheim, Alexandre Théron, Dominique Plantaz, Marie‐Dominique Tabone, Guy Leverger, Justyna Kanold, Sandrine Thouvenin‐Doulet, Zeinab Hamidou, Mohamed Boucékine, Julie Berbis, Pascal Auquier, Gérard Michel, Paul Saultier
DOI: 10.1016/j.jtct.2026.04.050
Cited by: 1
References: 25

Abstract

Hematopoietic stem cell transplantation (HSCT) is essential for curing high-risk or relapsed acute leukemia but entails lifelong morbidities. Adolescents and young adults may be particularly vulnerable; however, data on the global risk of long-term complications in survivors who underwent HSCT during adolescence are lacking. Using the French Leucémie Enfant Adolescent cohort, we compared late complications and quality of life (QoL) in survivors transplanted at ≥15 versus

Fields of Study & Subjects

Childhood Cancer Survivors' Quality of Life Acute Lymphoblastic Leukemia research Hematopoietic Stem Cell Transplantation

Publication details

Journal / source
Transplantation and Cellular Therapy
Publisher
Elsevier BV
Volume
32
Issue
9
Pages
1123.e1–1123.e12
Publication date
3 May 2026
Language
EN