P211. FTO m6A methylation orchestrates the inhibition of CD8+ T cell in tumor microenvironment of esophageal squamous cell carcinoma

Journal of Thoracic and Cardiovascular Surgery 2026 Open access

Read full text
Authors: Hecheng Li, Yan Yan, Wei Guo, Yichao Han, Wangyang Meng, Runsen Jin
DOI: 10.1016/j.jtcvs.2026.03.436
Cited by: 1

Abstract

Objective: Esophageal squamous cell carcinoma (ESCC), the predominant histological subtype of esophageal cancer, remains a major health burden with high incidence and poor prognosis, especially in Eastern Asia. Neoadjuvant chemoradiotherapy (nCRT) is the current standard for locally advanced ESCC, while adding immunotherapy may further improve outcomes. Beyond immune checkpoints, tumor cells in the tumor microenvironment (TME) evade immune surveillance via epigenetic mechanisms such as N6-methyladenosine (m6A) modification.

Fields of Study & Subjects

RNA modifications and cancer Cancer-related gene regulation Metalloenzymes and iron-sulfur proteins

Publication details

Journal / source
Journal of Thoracic and Cardiovascular Surgery
Publisher
Elsevier BV
Volume
171
Issue
4
Pages
S324–S324
Publication date
24 April 2026
Language
EN