Lung Adenocarcinoma Developing Pleomorphic Carcinoma With ERBB3 Amplification After Acquired Resistance to Sotorasib: A Case Report

JTO Clinical and Research Reports 2026 Open access

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Authors: Satoru Senoo, Kohei Takata, S Matsumori, Takahiro Baba, Yuka Sugisaki, Hiroki Omori, Hiroaki Matsuura, Yumi Matsuura, Rika Omote, Eiki Ichihara, Toshiaki Okada
DOI: 10.1016/j.jtocrr.2026.100994
Cited by: 1
References: 7

Abstract

Introduction: -positive nonsquamous NSCLC; however, the underlying mechanisms remain incompletely understood. Case: mutations. Postmortem examination revealed pleomorphic carcinoma. Conclusion: amplification may contribute to off-target resistance to sotorasib, and transformation to pleomorphic carcinoma may represent an additional resistance mechanism.

Fields of Study & Subjects

Metastasis and carcinoma case studies Salivary Gland Tumors Diagnosis and Treatment Lung Cancer Treatments and Mutations

Publication details

Journal / source
JTO Clinical and Research Reports
Publisher
Elsevier BV
Volume
7
Issue
7
Pages
100994–100994
Publication date
28 March 2026
Language
EN