Implementation and impact of the RTS,S/AS01 malaria vaccine on infants and implications for pregnancy in Rwanda: Operational and programmatic insights

Malaria remains a significant public health challenge in Rwanda, disproportionately affecting pregnant women. Despite existing control measures like Insecticide-Treated Nets (ITNs), Indoor Residual Spraying (IRS), and Intermittent Screening and Treatment in Pregnancy (ISTP), malaria transmission persists due to factors such as insecticide resistance. The RTS,S/AS01 (Mosquirix™) malaria vaccine offers a potential solution, demonstrating efficacy in reducing clinical malaria in children in clinical trials. This study aims to evaluate the potential impact of integrating the RTS,S/AS01 vaccine into Rwanda's infants' health programs. This study utilized existing data on malaria prevalence, vaccine efficacy, and healthcare infrastructure in Rwanda. Findings from this study will provide evidence-based recommendations for policymakers regarding the vaccine's incorporation into national malaria control initiatives, contributing to the pursuit of sustainable malaria elimination in Rwanda.